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With V-6 and V-8 engines and a choice of rear- or all-wheel drive, the 2008 Cadillac STS is quite competitive versus the mid-size luxury sedans from Germany and Japan, but it arguably doesn't look or feel as up-to-date as the 5-Series or E-Class inside.
In terms of performance, the base STS has perkier performance than either the E350 or the BMW 528i, though the sweet engine in the new 535i may have it beat.
The E-Class more closely fits a definition of traditional luxury, with a classy appearance, while the 5-Series and M35/M45 feel sportier from behind the wheel.
The Infiniti M models have a surprisingly roomy interior--including a spacious backseat, which is somewhat hard to find in this class--but the ride isn't as settled and road noise can be an issue.
And if you're especially green, you might want to consider the E320 Bluetec diesel, which returns standout highway fuel economy in the mid-30s.
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